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Reported fertility advantages include better cycle regularity, an increase in antral follicle counts in some women, improved sperm parameters in males, and decreased miscarriage risk in limited reports

Berberine alleviates cholesterol and bile acid metabolism disorders induced by high cholesterol diet in mice

Therefore, they provide a strong translational foundation for metabolic research applications

Indeed, because of their presence in almost every tissue and organ in the body, it is not surprising that fibroblasts are now implicated in multiple and diverse conditions ranging from well-known diseases like cancer, rheumatoid arthritis or fibrosis, to poorly understood ones like fibromyalgia, chronic pain or thyroid eye disease, as we will discuss below ( Figure 1 )